14/03 Human and viral genomics of infections

My research program focuses on the identification of human and viral genetic factors that can explain the observed variability in the natural history of infectious diseases, particularly those caused by viruses. I use approaches of statistical genetics, such as genome-wide association studies or candidate gene association study, as well as more original approaches, using family information to estimate the familial correlation of a trait or combining linkage analysis and association analysis within families. In addition, I contributed to the development of a novel method to explore the interactions between the whole human genome and the whole virus genome by jointly analysing genotyping and sequencing data in a regression framework.

In this talk I will present details of the bioinformatics pipeline do generate the data from the host and the virus and the results from my research on hepatitis C virus and dengue virus