Domitille Chalopin-Fillot

LncRNA expression during cell differentiation

Studying cell differentiation has been revolutionized by the advent of single cell technologies. Moving beyond a stepwise view, we now depict a continuum process containing a range of intermediate cell states expressing different transcriptomic programs. Up to now, the annotation and understanding of these intermediate states mostly relied on protein-coding

Open Positions

Stage M2: Regulation of the suppressive function of myeloid cells by long noncoding RNAs in cancer.

We are looking for a highly motivated M2 student willing to explore how lncRNAs regulate the acquisition of functions and cell differentiation process using temporal transcriptomic data.

Seminars

25/04 Florian Mueller : Exploring spatial transcriptional regulation by quantitative imaging

Integrated quantitative imaging analysis approaches to study sub-cellular RNA localization and its link with translation. Spatial transcriptomics data analysis will be covered too

Seminars

21/02 Professor Daniel Gautheret : RNA discovery in tumor samples through k-mer analysis

Orateur : Daniel Gautheret, Institute for Integrative Biology of the Cell, CNRS, CEA, Université Paris-Sud, Orsay Lieu : Centre de Génomique Fonctionnelle (salle des conférences, 1ème étage) Titre: "RNA discovery in tumor samples through k-mer analysis" Abstract: I will present the use of k-mer tools for reference-free analysis of RNA-seq

Projects

Exploiting innate immunity of hepatocellular carcinoma to improve patients treatment

Analysis of HCC tumour etiology based on multi-omic datasets including scRNAseq, spatial scRNAseq, bulk RNAseq and 16S microbiome sequencing

Team

About us

Computational Biology and Bioinformatics is an interdisciplinary team at the CNRS institute in Bordeaux focused on multi-omics and imaging data integration. Our two main pillars are 1) Tackling real biological problems and 2) Combining different areas of technical expertise ...